Affymetrix Inc. pioneered the field of oligonucleotide microarrays and has been the microarray ”gold standard” for fifteen years now. Affymetrix’ GeneChip™ technology applies a combination of photolithography and combinatorial chemistry to directly synthesise oligonucleotides on a glass surface. Up to 6.5 million different oligonucleotides are synthesised on a 1.7 cm² surface – an area as small as a thumbnail. Affymetrix was also among the first companies in the field to launch human whole-genome SNP genotyping chips. In addition, whole-genome SNP genotyping chips are available for various model organisms including mouse.
ATLAS Biolabs´ Affymetrix SNP Genotyping Service leverages the full potential of this technology: speed (up to 900,000 SNPs are simultaneously determined), the low amount of genomic DNA needed (200–500 ng), high call rates >99%, and high accuracy.